Aug 23, · “Spermicidal lubes or certain condom materials can have a harsh effect on penis skin,” says Cohen. If you use latex condoms, you may have a . The bad news about urethral irritation in men is that it can be due to a bacterial infection. Changing brands of condoms, or avoiding sex altogether for that matter, won't make a difference. Just about the only way to get over a UTI is prescription antibiotics, and it .